The service area of the school was expanded by 1995 legislation that divided West Virginia into eleven districts.

Southern serves all of Boone, Lincoln, Logan, McDowell, Mingo, and Wyoming counties.

In 2021, new college president Pam Alderman changed the school colors from gold and black to a light blue.

[8] Prior to the early 2020s, Southern campuses were located in Mount Gay, Williamson, Foster, and Saulsville, with a site in Hamlin.

[9] Another campus was lost later in 2024 when the Boone County Board of Education ejected Southern from its shared building.