The Southern and Eastern Serbia (Serbian: Јужна и источна Србија, romanized: Južna i istočna Srbija) is one of five statistical regions of Serbia.

In 2009, the National Assembly adopted a law which divided Serbia into seven statistical regions.

However, in 2010, the law was changed, thus the Eastern and Southern regions were merged into a single statistical region named Southern and Eastern Serbia.

Most critical situation is in municipalities of Gadžin Han, Crna Trava, Ražanj, Trgovište, Dimitrovgrad, and Bosilegrad.

A stark example of depopulation is Crna Trava, which used to have 13,614 inhabitants in 1948, while in 2022 only 1,063 people were registered.