The adoption of initiatives in this field by the Council of Europe and the International Olympic Committee (IOC), promoted the participation of Spain in the first meeting of the special study group on doping of athletes, which was held in 1963 at the proposal of the European body.

The application and development of the 1990 Act also meant the entry into operation of the National Anti-Doping Commission (CNA), the immediate predecessor of the current agency.

[5] Among other responsibilities, this law entrusted the agency with carrying out controls on doping in sport and competencies on research policy in the area of prevention, doping control and protection of the health of athletes, with the aim of facilitating up-to-date knowledge of scientific and technological advances in this field, thus allowing an efficient approach to the fight against this phenomenon.

[7] In 2013, Organic Act 3/2013, of June 20, on the protection of the health of athletes and the fight against doping in sports activity, was approved, a legislation that replaced the previous one from 2006.

[11][10] Again, this project was aimed at adapting national legislation to the new World Anti-Doping Code of 2021 and, among other things, renamed the State Agency as the Spanish Commission for the Fight Against Doping in Sport, since the current name did not correspond with its real powers, which were modified in 2017.