The 2005 and 2006 seasons saw Spartakos successfully defending the Greek Championship by beating Aris Baseball and Mylon Neas Smyrnis in the finals, respectively.

In the opening day of the final four group stage Spartakos easily defeated Eyriali Glyfadas 19–0.

What Panthers Patras failed to do at the 2009 season they did at 2010 when they upset the (5 times in a row) defending champions Spartakos to win the 2010 Greek title.

It was a close encounter and after twelve innings Spartakos managed to score the last run and win the match 9–8.

Next season which had the old format of semifinals and finals (all contested in series ) return, found Spartakos struggling to fourth place with two games remaining after losses to Aris Baseball, Marousi 2004 and Eyriali which hurt the chances of Spartakos for first place in the regular season.

Although Spartakos looked ready to win the series and reclaim the title they lost both of the remaining games and finished as runners-up to the 2011 championship.

After this heartbreaking loss Spartakos had to win all the remaining games of the series to avoid a third consecutive championship failure.

With the danger of losing the title for another year Spartakos played one of their best games of the season winning by mercy rule 15–5 at 6,5 innings.

But in the end Spartakos held their lead and won 10–8, making this the biggest comeback in Greek baseball series history.

The 2013 season started with Spartakos participating to the Greek Cup tournament and after three easy wins against Dias Patron, Aris Baseball and Olympiada Peristeriou was eliminated to the semi-finals of the double elimination bracket after two consecutive close losses to Leaders Vouliagmenis thus failing to defend the Greek Cup trophy successfully.

The season opener found Spartakos facing Evriali Glyfadas and won fairly easily 13–2.