The healthcare system contains hospitals in Spartanburg, Union, and Cherokee counties, its primary service area.

With a total of 747 beds, Spartanburg Medical Center offers diagnosis and treatment for Upstate South Carolina residents.

HERT was developed after Spartanburg Regional mobilized personnel to assist in the National Disaster Medical System (NDMS) operations during hurricanes Katrina and Rita in 2005.

Spartanburg Regional Healthcare System operates the Medical Group of the Carolinas, a network of more than 120 practices.

The regional outpatient service sites of care offer a wide range of diagnostic, laboratory, and invasive tests and procedures.

SpaceOAR is the first FDA-approved procedure for placing a ‘spacer’ to protect the rectum of men undergoing prostate cancer radiation.

Daniel Fried, MD, PhD, medical director and radiation oncologist at Gibbs Cancer Center & Research Institute - Pelham, was the first trained and certified physician in the Carolinas to use SpaceOAR.

Ellen Sagar Nursing Center in Union, South Carolina, became a division of Spartanburg Regional Healthcare System in 2015.

SMC also offers a minimally invasive approach to surgery with the da Vinci® robotic surgical systems.

SMC also offers a variety of outpatient pediatric services, including educational programs on parenting issues and children's health and wellness.

The inpatient Psychiatry Unit operates 28 beds and is located on the third floor of the main hospital building.

Post-Acute Services: In addition to the post-acute facilities described above, the district provides Home Health, Palliative, and Hospice Care in a variety of settings: Home Health provides 10,800 episodes of care for residents of Spartanburg, Cherokee, Union, and Greenville counties for individuals who are recovering from illness or surgery, injury, undergoing treatment, disabled, or chronically ill. Services include skilled nursing, physical therapy, occupational therapy, speech therapy, medical social services, aides, wound care, infusion, and enteral services and telehealth.

This program coordinates the services of physicians, nurses, chaplains, social workers, volunteers and other specialists to care for nearly 11,000 patients a year.

The 1929 stock market crash resulted in the closure of more than 700 hospitals across the country between 1928 and 1938, but Spartanburg General remained open.

Farmers brought chickens, fruit and vegetables as payment on accounts, and their produce and livestock was used to feed the patients.

It was one of the oldest American College of Surgeons (ACOS) Commission on Cancer-approved cancer programs in the nation.

In the 1940s, a wing added to the south end of the hospital contained 63 private rooms, a new surgical suite, and other modern facilities.

That same year, the ‘Gray Ladies’ began their service of guiding patients to their rooms from the admitting office.

In February 1967, hospital officials signed an agreement with University of South Carolina (USC) trustees to establish USC-Spartanburg (now known as USC-Upstate) complete with a nursing school.

In 1968, Spartanburg General added a new data center to handle a modern phenomenon: a tsunami of information.

Also in 1968, due to growing services, Mary Black Memorial Hospital moved from East Main Street to its current location on Skylyn Drive.

John C. West presided over the groundbreaking ceremony for the $3.5 million ambulatory care, education and administration building.

The building offered a modern outpatient service unit and an emergency department equal to the task of serving 40,000 patients a year.

In 1988, medical advancements included Hyperbaric Oxygen Therapy and Magnetic Resonance Imaging (MRI).

Designed to meet new demands for patient comfort and family involvement, the Tower also brought services physically closer to one another to make the operation of the hospital more efficient.

The Rx Robot entered the scene in 1997, continuing the hospital's role as an important innovator in health care.

While directors and physicians had been planning the facility for several years, a $1.2 million gift from the Marsha and Jimmy Gibbs family accelerated its construction.

SRHS also joined forces with Bon Secours St. Francis Health System to expand services and research.

Innovative technology investments during this era included Gibbs being the first hospital in the state to offer TomoTherapy, a target form of radiation therapy.

In addition, Gibbs Pelham was the first hospital in the Upstate to use the CyberKnife Robotic Radiosurgery System, a surgery-free radiation therapy.