The Spatsizi River is a tributary of the Stikine River, rising near Mount Gunanoot in the southeastern Spatsizi Plateau, British Columbia.

The Spatsizi River emerges near the foot of Mount Gunanoot in the Skeena Mountains of north-central British Columbia.

It then flows downslope and enters Spatsizi Headwaters Provincial Park from the south.

The river continues north, leaving the park to enter a broad valley in the heart of the Spatsizi Plateau.

This article related to a river in the Interior of British Columbia, Canada is a stub.