Directed by Brad Turner and stars Robin Dunne, Robert Knepper, Sunny Mabrey, Amelia Cooke and John Paul Pitoc.
Natasha Henstridge, who was contracted to a trilogy commencing with the first Species film, briefly reprises the role of Eve in the opening scene.
The film premiered on the American channel Syfy on November 27, 2004, and released on DVD on December 7, in both a standard and an unrated version.
Abbot tries to treat Portus, who demands to see Sara and reveals that there are other half-breeds suffering from similar illnesses.
Meanwhile, one of Abbot's students is called Dean, and his funding for an experimental power plant project is in jeopardy.
Dean's roommate at the university, Hastings, discovers a website posted by Amelia, a woman who wants to date biochemists.
En route, Amelia - who is another half-breed - has sex with and murders a gas station attendant who attempts to rape her.
Wasach, whose team also monitored Amelia's website and discovered its connection to Project Athena, picks up Dean and helps him save Hastings.
Dean reveals that he pulled Sara to safety before sealing the plant's core, then completed the refined alien DNA to create a mate for her so she would not be alone.
Dean then reassures the nervous Hastings by revealing that he ensured that Sara's mate would be sterile, preventing them from reproducing.
Executive producer Frank Mancuso Jr., who also worked on the previous Species films, wanted the sequel to be aimed more at young adults, so the characters were written to be younger than what was originally planned.