Several alternate reality incarnations of the character have additionally received notoriety, including the Ultimate Spider-Woman, Ashley Barton, and Gwen Stacy.

Marvel Comics' then-publisher Stan Lee said in 1978, shortly after Spider-Woman's debut in Marvel Spotlight #32 (Feb. 1977) and the start of the character's 50-issue self-titled series (cover-dated April 1978 – June 1983), the character originated because, I suddenly realized that some other company may quickly put out a book like that and claim they have the right to use the name, and I thought we'd better do it real fast to copyright the name.

Veranke is a Super-Skrull and a queen of the Skrulls who impersonated Jessica Drew / Spider-Woman over a long period of time and was a founding member of the New Avengers.

In the pages of Old Man Logan, Ashley Barton is the daughter of Tonya Parker and Hawkeye who did not like the way that Kingpin was running Hammer Falls.

[9] The character appears in the "Spider-Verse" and Spider-Geddon storylines, now referred with her father's surname as Ashley Barton, and alternately referred to as "Spider-Girl" and "Spider-Woman" due to the family-friendly nature of the narrative, and is among the spider-powered characters who are recruited by Superior Spider-Man (Doctor Octopus's mind in Peter Parker's body) to help fight the Inheritors, before returning to the Wastelands in "Venomverse" and "Old Man Quill".

For the first ten years of their lives, the two were solely raised by Mary Jane in Portland, Oregon after she left Peter following a traumatic incident.

When Benjy discovers that Morlun is vulnerable when he is feeding off someone, he uses himself as bait to allow Claire the chance to impale him on a splintered log of wood.

[13] During the Web Warriors ongoing series, on accidentally coming across actors Felix Lifson and Erin Hasko, in a world where Spider-Man is fictional, shooting a Spider-Man movie (in which Erin is playing Gwen "Spider-Gwen" Stacy / Spider-Woman), Octavia Otto and the Web Warriors invite the duo to join the team, initially not noticing the pair to be actors shooting the film.

On clearing up the misunderstanding, Octavia nonetheless makes the offer again, if either of them would be open to it, and excitedly noting that she learned three different types of martial arts for a previous role, Erin joins the Web Warriors and ventures into the multiverse with them, leaving her shocked crew behind, as Felix asks if they were still filming.

[14] Erin returns in the video game Spider-Man Unlimited, now wielding a specialized set of web-shooters made for those lacking spider-strength as a "real" Spider-Woman.

Mayday Parker, Peter and MJ's daughter from the alternate future MC2 who is commonly known as Spider-Girl, began calling herself Spider-Woman after her father's death.

In the Squadron Supreme series, Nell Ruggles was a young troubled girl, who upon gaining her powers killed her classmates, who had bullied her in the past.

Thanks to an electroshock collar, she has been prevented from leaving, though she appears to be making the best of the situation, having made friends and eventually falling in love with Tucker Ford, Biogeneral.