He built up a number of business interests in the areas of shipping, real estate, construction and oil, plus banking and finance.

Latsis invited the President of the European Commission, José Manuel Durão Barroso, who had been a student friend at the University of Geneva,[7] to be a guest on his yacht.

EFGI's group of private banking businesses operates in around 30 locations worldwide, with 3,151 employees and manages CHF153.8bn of client assets as of December 2019.

Latsis also started PrivateAir, a jet charter service with over 50 planes in its repertoire serving affluent European and American travelers, and which he has since sold.

[14] The investigation, which began on 15 January 2020, reportedly concerns suspected bribery of Fahad Al Rajaan, the former director of Kuwait's Public Institution for Social Security (PIFSS).

Al Rajaan, who is now deceased, allegedly received commissions in exchange for awarding mandates to manage public funds to several Swiss banks.

In 2012, he transferred around $300 million of his Greek banking stock holdings to various members of the Latsis family, with a contribution also going to the Foundation.

[13] The John S. Latsis Public Benefit Foundation helps to fund programs in the areas of education, scientific research, social welfare, and culture.