Recently, evidence has been obtained for a tolerogenic effect of a spleen transplant in miniature swine.
[citation needed] Also, the spleen harbors primitive hematopoietic progenitor cells.
Usually this involves leaving parts of splenic parenchyma in pouches of omentum.
This was performed after splenosis was understood; splenosis is the spontaneous reimplantation of splenic tissue elsewhere in the body (usually the abdomen) after it has broken off from the spleen due to trauma or surgery.
[3] According to a 2020 review of 18 experimental studies, the transplanted spleen appears functional, with 95% of re-implanted tissue undergoing regeneration (by scintigraphy) and 90% of patients having a normalized blood film (suggesting functional blood filtration).