[1] Pathological spontaneous orgasms can be experienced as pleasurable, non-pleasurable, or unpleasant, and can be distressing.
[1][2] Causes of pathological spontaneous orgasms include spinal cord lesions, psychological causes, rabies, and medications.
[1] Spontaneous orgasms may have no trigger or may be triggered by various non-sexual circumstances (e.g., urination, defecation, glans touch, anxiety, panic attacks, school examinations).
[2] Treatment of spontaneous orgasms include psychotherapy, selective serotonin reuptake inhibitors (SSRIs) (e.g., paroxetine, citalopram, sertraline), the alpha-1 blocker silodosin, and anxiolytics.
[1][2] This has included selective serotonin reuptake inhibitors (SSRIs) (e.g., citalopram, escitalopram, fluoxetine, sertraline), serotonin–norepinephrine reuptake inhibitors (SNRIs) (e.g., venlafaxine, milnacipran, duloxetine), norepinephrine reuptake inhibitors (NRIs) (e.g., atomoxetine, reboxetine), norepinephrine–dopamine reuptake inhibitors (NDRIs) (e.g., methylphenidate, bupropion), tricyclic antidepressants (TCAs) (e.g., imipramine, desipramine), monoamine oxidase inhibitors (MAOIs) (e.g., rasagiline), serotonin antagonists and reuptake inhibitors (SARIs) (e.g., nefazodone), psychostimulants (e.g., methylphenidate, dextroamphetamine), typical antipsychotics (e.g., zuclopenthixol, trifluoperazine, thiothixene), and atypical antipsychotics (e.g., olanzapine, aripiprazole, zotepine), among others.