After the completion of his studies in Corfu, he continued them in Naples and Milan under various teachers including Niccolò Antonio Zingarelli.

In the 1840s, Xyndas began to compose concert arias and songs in demotic Greek, a contribution that eventually resulted to the creation of the opera called O ypopsifios (The Parliamentary Candidate) in 1867.

Its seemingly comic plot is a severe criticism regarding the living conditions of the Ionian Islands' rural society, against the morality of the indigenous politicians, both during the period under British occupation (1815–1864) and after it.

The 1888, the success of his 'Candidate' Athens, which became the occasion for the creation of the First melodramatic troupe composed of Greeks,[6] led Xyndas and his family to the capital of Greece, where he died in 1896.

[7] It is believed that many of his works were destroyed during the 1943 Luftwaffe bombing of the Municipal Theatre of Corfu.