Squash competitions at the 2023 Pan American Games in Santiago, Chile were held at the Centro de Entrenamiento del Tenis y Deportes de Raqueta from October 31 to November 5.

A total of 50 squash athletes (25 men and 25 women) will qualify to compete.

Each nation may enter a maximum of 6 athletes (three per gender), except for the NOCs that have qualified in Cali 2021.

The host nation, Chile automatically qualified the maximum team size.

Other seven men's and women's teams (of three athletes) will qualify through different qualification tournaments.