Its first director was the German Florián Blümel of the Society of the Divine Word, who arrived along with Albino Seeger.

In 1922 the school moved to a new building built by the architect Cousiño Calavera in Baquedano.

In 1935 Blümel asked the new archbishop Alfredo Cifuentes Gómez to look for a teaching congregation to take charge of the school.

In 1988 the municipality of Antofagasta gave the name of Nicanor Marambio to a complex located in the Bonilla settlement, in the northern sector of the city.

After the coup d'état of September 1973, thanks to the personal contacts of Renato Hasche who was rector at that time, it was possible to exempt San Luis from the branch of National Security Doctrine that had been imposed by the military regime.