St. Ambrose High School was a coeducational Catholic high school in Grosse Pointe Park, Michigan, United States.

In 1959, St. Ambrose faced a much larger Detroit Cooley team, which was ranked number one in Class A, in what appeared to be a classic mismatch.

[4][5] From 1957 to 1967, St. Ambrose produced five football All-Americans and 12 All-State players.

Two St. Ambrose players, Tom Beer[6] and Gary Nowak,[7] played in the National Football League.

Two of the coaches, Tom Boisture and his successor George Perles, would go on to win a combined six Super Bowl rings in the NFL.