The school, a part of the Roman Catholic Diocese of Austin, opened in August 2009.

The high school is named after Saint Dominic Savio, the youngest non-martyr ever canonized.

[5] St. Dominic Savio competes in the Texas Association of Private and Parochial Schools, fielding varsity teams in the following sports:[6] Saint Dominic Savio has an active fine arts program which includes annual performances of plays and musicals.

[7] It also competes in the Texas Association of Private and Parochial Schools in Music and Art.

[8] All of their large instrumental ensembles and four of their five choirs qualified for the state competition:[9] Saint Dominic Savio was TAPPS 5A overall Academic and Speech champions in 2017, 2018 and 2023.