Saint Francis of Assisi is a Roman Catholic church founded in 1902 in Toronto, Ontario, Canada.

It is located in the west end neighbourhood of Little Italy and Trinity-Bellwoods and within the Roman Catholic Archdiocese of Toronto.

The original church and parish community of St. Francis of Assisi was established in 1902 on the corner of Dundas and Grace Street.

During the construction of the original church, Mass was celebrated in 1902 and the first part of 1903 at St. Francis of Assisi Separate School located at the time on Manning Avenue.

William Alfred McCann, made a Prelate of Honour of His Holiness Pope Pius XI on September 29, 1935.

Holmes designed numerous churches and buildings for the Archdiocese of Toronto including St. Augustine's Seminary.

The decoration intensifies in the transepts and into the sanctuary to emphasize the importance of that sacred space and the beauty of the East stained glass window, depicting the Crucifixion of Christ.

The entire sanctuary area was restored to its original design with the reconstruction of Holmes' ambulatory screen as the backdrop of the altar.

The restoration of the coffered ceiling artwork over the sanctuary was donated by a parishioner of the Italian community in memory of his late wife.

This organ includes some interesting innovations such as brass pipe lips and thin-walled lead principals.

Massimo Buttigieg, 2022 to Present "St Francis of Assis Church, Toronto's tribute to the Italian saint".