In 1918 St. John's Hospital was turned over to the city of St. Paul during the flu epidemic to care for charity patients.

In 1985, St. John's Northeast Hospital was built at its current Maplewood, Minnesota location.

The former location of St. John's Hospital is now home to Metropolitan State University.

St. John's is currently a member of the M Health Fairview family of care.

St. John's was the first community hospital in the Twin Cities to offer a robot-assisted surgical system as a treatment option for prostate cancer patients.