St. John's Hospital, founded in 1875 by the Hospital Sisters of St. Francis, has 457 licensed beds and is a primary teaching hospital for the Southern Illinois University School of Medicine (SIU).

Located in Springfield, Illinois, St. John's is a member of the Hospital Sisters Health System (HSHS), a Roman Catholic healthcare mission founded to continue the healing ministry of Jesus Christ.

[2] St. John's is one of two Level One Emergency Trauma Centers a distinction it shares with Memorial Medical Center (MMC) (Springfield, Illinois) and only Level 2 Pediatric Trauma Center for the Springfield area.

[3][4] St. John's is the home to the Prairie Heart Institute and AthletiCare.

This article relating to a hospital in Illinois is a stub.