The date of 1625 is carved on the Saxon font and on the porch but it incorporated an earlier building, believed to have been a tithe barn or a farmhouse.

The vestry was added at the side of the original rectangular building in 1715.

[1][2] St Anne's Church was converted to a school following the completion of the new Buxton parish church of St John the Baptist in 1811.

[3] The Methdodist preacher John Wesley delivered a sermon in the church when he visited Buxton on 24 May 1783.

[4] The 18th-century Irish comedy actor John Kane was buried in the graveyard in 1799 (after he died mistakenly eating hemlock or wolf's bane).