Stapeliopsis is a genus of succulent plants in the family Apocynaceae, native to southern Africa.

The name refers to its superficial resemblance to some species of the genus Stapelia (Greek "-opsis" = "look-alike").

[3] The stems are four-angled in cross-section, often with lines of teeth along the angles.

They appear from the base of the stems and often are born underground (especially in the case of Stapeliopsis pillansii.

Only Stapeliopsis saxatilis is relatively widespread in rocky areas of the Cape.