Between 1953 and 1954 the Christian Brothers established a congregation in Uruguay and founded a school for boys in the exclusive suburb of Carrasco.

They had an organizational committee composed of the Moor family, Davie, Surraco Germain, Manuel Pérez del Castillo and Stella Ferreira, Adolfo Gelsi Bidart, Enrique Rozada, Antonio Barreiro, Conrad Hughes, Francisco Ferrer, Rodolfo Anaya, Antonio Galan, Eduardo Strauch and Jorge Alvarez Olloniego.

They also worked with Gallinal Alberto Heber, William Strauch, Roberto Houni, Jorge Eduardo Aznárez and Berenbau.

The school's current location on the street of Tajes Max opened on March 12, 1961 with the blessing of Cardinal Antonio María Barbieri.

A system of "Houses" (Casas) was instituted in 1963, which categorizes all students into four groups: Prior, Sion, Iona and Newman, each with a color identifier.

In 1976 this area was completed with the construction of a second high school section that included a library and laboratories for physics, chemistry and biology.

The school gained accidental fame when its alumni rugby team crashed in the Andes mountains on October 13, 1972, on Uruguayan Air Force Flight 571.

The remaining survivors endured hunger, crash-related injuries, altitude sickness, and temperatures that fell to 30 degrees below zero at night.

On December 12, 3 of the remaining survivors set out to find help, hiking west across the Andes Mountains to reach Chile.