Stemmadenine is believed to be formed from preakuammicine by a carbon-carbon bond cleavage.
Cleavage of a second carbon-carbon bond is thought to form dehydrosecodine.
[1] The enzymes forming stemmadenine and using it as a substrate remain unknown to date.
It is thought to be intermediate compound in many different biosynthetic pathways[2][3][4] such as in Aspidosperma species.
Some of them are: It is also present as product in plant like in Tabernaemontana dichotoma seeds.