[3] His first professionally published comics artwork was a one-page parody of the "I…Vampire" feature in House of Mystery #306 (July 1982).
He then teamed with writer Bob Rozakis to create 'Mazing Man, a character introduced in an eponymous series beginning in January 1986.
[5] After the cancellation of that series, the Rozakis-DeStefano team created Hero Hotline in Action Comics Weekly #637 (January 1989).
[6] After a four-issue run as a back-up feature, Hero Hotline received its own six-issue limited series.
[10] In 2020, DeStefano won the Outstanding Individual Achievement in Animation Emmy for Character Design on the Genndy Tartakovsky series Primal.