He was signed by the Indianapolis Colts as an undrafted free agent in 2022 after playing college football at Miami (OH).

[1] In his freshman season, he was named Defensive Scout Team Player of the Year, before playing in twelve games as a sophomore, starting one.

In 2019, he finished second on the team with ninety-eight tackles, helping Miami defeat Central Michigan for the MAC Championship.

[9] Colts GM Chris Ballard was reportedly "upset" that the Bears claimed Weatherford, hoping to re-sign him to the team's practice squad.

[11] On July 26, 2023, Weatherford was claimed off waivers by the Los Angeles Rams,[12] but was waived two days later with a failed physical.