His work with CAE is considered pioneering in the areas of politically engaged art, interventionist practices, and cultural research and action in the field of biotechnology and ecological struggle.
Kurtz's arrest in 2004 for suspected “bioterrorism” is the subject of a film, Strange Culture, by Lynn Hershman Leeson, and served as inspiration for the novel Orfeo by Richard Powers.
Since its formation in 1987 in Tallahassee, Florida, CAE has been frequently invited to exhibit and perform projects examining issues surrounding information, communications and bio-technologies by museums and other cultural institutions.
At the time of Hope Kurtz's death they were working on an exhibit about genetically modified agriculture for the Massachusetts Museum of Contemporary Art.
Buffalo police deemed these materials suspicious and notified the FBI, who detained Kurtz for 22 hours without charge on suspicion of "bioterrorism."
Also indicted was Dr. Robert Ferrell, Professor of Genetics at the University of Pittsburgh Graduate School of Public Health, who served as a scientific consultant on Critical Art Ensemble's projects.
[citation needed] On April 21, 2008, the indictment for mail and wire fraud was ruled "insufficient on its face" by the presiding Judge Richard Arcara.