Khoury grew up in Bethlehem and attended Baptist Bible College in Springfield, Missouri, where he earned a bachelor's degree in pastoral ministry and theology.

The organization provides health and financial aid to needy families in the region and supports the largest evangelical Arab ministries in the Holy Land.

[2][4][5][3] In the late 2000s, following a meeting with David Nekrutman of the Center for Jewish–Christian Understanding and Cooperation (CJCUC), the two decided work together to help the disadvantaged and persecuted Christian community living in Bethlehem and its surrounding areas.

[7] In July 2014, the congregation of Calvary Baptist Church, which Khoury ministers, was evicted out of their building in the Shuafat area of Eastern Jerusalem after Islamists threatened their landlord.

[10] In 2023, Khoury, along with members of The Isaiah Projects organization, led a humanitarian effort to save Dina, a Gazan woman whose husband was murdered over a property dispute.