[2][3] The series was home to one of the last superheroes of the pre-Silver Age of Comic Books era, Captain Comet, created by writer John Broome and artist Carmine Infantino in issue #9.

[7] In "The Strange Adventure That Really Happened" in issue #140 (May 1962), real life comics creators editor Julius Schwartz and artist Sid Greene struggle to make writer Gardner Fox recall a story he has written that holds the key to saving the Earth from alien invasion.

Writer Bob Haney and artist Howard Purcell created the supernatural character the Enchantress in Strange Adventures #187 (April 1966).

Deadman's first appearance in Strange Adventures #205, written by Arnold Drake and drawn by Carmine Infantino,[11] included the first known depiction of narcotics in a story approved by the Comics Code Authority.

These plans were put on hold that year due to the DC Implosion, a line-wide scaling back of the company's publishing output.

In 1999, DC Comics' Vertigo imprint released a four-issue mini-series reviving the Strange Adventures title and concept.

Artists included Edvin Biuković, Richard Corben, Klaus Janson, Frank Quitely, James Romberger, and John Totleben.

[17] An 80-page Strange Adventures #1, an anthology one-shot, with short science fiction and fantasy stories was released with a July 2011 cover date.