Perperoglou began his playing career with the youth clubs of AO Kavalas and Iviskos.

[2] On 23 July 2015 he left Efes and signed a two-year deal with FC Barcelona Lassa.

[4] On 3 August 2018 Perperoglou moved to Serbia and signed for Crvena zvezda for the 2018–19 season.

In July 2021, Perperoglou announced his retirement from his basketball career at age 36.

Perperoglou has also played with the Greece men's national basketball team, and they won the bronze medal at the 2009 EuroBasket.