Strother Creek is a stream in southwest Iron and northern Reynolds counties in the U.S. state of Missouri.
The stream headwaters arise in southwestern Iron County just south of Buick and the Buick Mine and east of Missouri Route KK.
The stream flows south for about one-half mile then turns to the east to flow adjacent to the Iron-Reynolds county line and crossing the county line a number of times.
The stream reaches its confluence with the Middle Fork Black River just south of the county line and west of Missouri Route 49 and about two miles northwest of Edgehill.
[2] The upper portion of the stream contains several tailings pond areas from the mines near its source.