The song debuted atop the Billboard Hot 100, chart issue dated May 23, 2020, becoming Grande's third and Bieber's sixth U.S. number-one single.

The song also debuted at number one on the Rolling Stone Top 100, chart issue dated May 21, 2020, becoming Grande's second and Bieber's first number-one single.

Internationally, The song also topped the charts in Canada, Lebanon, Malaysia, New Zealand, Israel, and Singapore; and reached the top-ten in 17 other countries.

[9][10] During an ASCAP interview, co-writers Gian Stone and Whitney Phillips revealed that the song was originally meant to be a solo performance and that it was Grande's idea to turn it into a duet with Bieber.

Anna Gaca of Pitchfork stated "Stuck with U" is "merely serviceable as a pop song" but "a big upgrade from that other product of rich-people lockdown culture: the celebrities singing 'Imagine'.

Instead of a bad take on a hoary classic, Grande and Bieber offer a new song with a pleasantly retro doo-wop vibe.

The song sales was aided by a variety of physical/digital combination offerings during the tracking week, including copies autographed by Grande and Bieber.

"Stuck With U" is also the third female-male duet in over a year since "Señorita" by Shawn Mendes and Camila Cabello and "Shallow" by Lady Gaga and Bradley Cooper to top the Hot 100.

[23] In an Instagram post, 6ix9ine alleged that the artists used six credit cards to buy 30,000 copies of "Stuck with U" without providing evidence.

Billboard stated that 6ix9ine's "six credit cards" claim was inaccurate, as bulk purchases are recognized and removed from the final sales total.

They also stated that the Hot 100 forecast he had referenced in an earlier Instagram post prior to the release of that week's chart reveal was not created by them and that they do not distribute any of their rankings to labels, management, or artist.

It consists of clips sent in by young fans who would have attended prom in 2020 but are unable to do so due to the COVID-19 pandemic, as well as people who are stuck inside spending time with loved ones.

It also features shots of celebrities like Kendall and Kylie Jenner, Demi Lovato, 2 Chainz, Paula Abdul, Stephen and Ayesha Curry, Elizabeth Gillies, Gwyneth Paltrow, Eric Stonestreet, Chance the Rapper, Kate Hudson, Lil Dicky, GaTa, Sheel Mohnot, Michael Bublé, Jaden Smith, Ashton Kutcher and Mila Kunis, as well as Bieber with his wife Hailey Bieber.