[7] Monactinal tylosyles and a small fraction of diactinal oxeas make up the megascleres found in the skeleton of S.

[7] Sponges are found in a variety of different marine benthic environments due to its early existence in evolution.

[8] Many species of hermit crabs can be found within the Suberites domuncula sponge in the Mediterranean Sea.

[12] S. domuncula produce a bacterial quorum sensing molecule, N-3-oxo-dodecanoyl-L-homoserine lactone, that limits the host immune and apoptotic responses.

[12] These sponges act as filter-feeders, driving a large amount of water through a highly vascularized canal system.

[11] Gemmules still survive upon the death of the sponge, persisting in harsh conditions for prolonged periods of time.

[11] Sexual reproduction involves the release of free-swimming larvae which then develop into juvenile sponge.

[7] This species also inhabits Wnt signaling, which is responsible for cell communication, specifically cell-fate decisions, tissue polarity, and morphogenesis.

[7] Dissociated single cells from Suberites domuncula form multicellular aggregates, known as primmorphs.

[11] These primmorphs are organized into a unicellular epithelium-like layer consisting of pinacocytes and spherulous cells.

[13] Sponges are shown to express a myotrophin-related molecule that aligns with the vertebrate cardiac mytotropin.

[9] These sponges maintain a direct defense strategy through the production of antibacterial compounds that prevent epibiosis.