Pratt is best known for her roles in daytime television as Anne Logan on General Hospital (1978–1982), Claire Ramsey on Guiding Light (1983–1986, 2000–2002), and Barbara Montgomery on All My Children (1987–1991, 1995, 1997, 1998, February 9-July 12, 2007).
She was also credited as Susan O'Hanlon in the role of Captain Nicole Davidoff (16 episodes, 1978–1980) in the Saturday morning series, Jason of Star Command.
Those roles include sweet nurse Anne Logan (Audrey Hardy's niece) on General Hospital (1978–1982), tough doctor Claire Ramsey (who had an affair with Ed Bauer, giving birth to his daughter, Michelle) on Guiding Light (1983–1986, 2000–2002), and ambitious businesswoman Barbara Montgomery (Travis's ex-wife who married Tom Cudahy but continued to sleep with Travis) on All My Children (1987–1991, 1995, 1997, 1998, February 9-July 12, 2007).
She had short-term roles on Loving and As the World Turns before making return appearances to both "AMC" and "GL".
For her role as Barbara Montgomery Cudahy, she received a Soap Opera Digest Nomination for Best Supporting Actress.