[12] On the night of December 23, 2007, ABS-CBN Channel 2 aired Alay ni Da King: a Fernando Poe Jr. Special, hosted by Charo Santos-Concio.

Jose Perez, founder and head of the film studio, offered Roces a contract on the spot leading to her first starring role in Boksingera.

[2] Roces also starred in several Philippine feature films including Ang Daigdig Ko'y Ikaw (1965), Gumising Ka Maruja (1967), Patayin Mo Sa Sindak Si Barbara (1974), Maligno and Mano Po 2: My Home (2003).

[10] During her career as a celebrity endorser, she appeared in various brands including Coca-Cola, Lux, Blend 45, and Lavoris, as well as on TV commercials of RiteMed and Champion Detergent.

In Sineserye Presents: The Susan Roces Cinema Collection (2008–2009), she played the character "Amanda" in the TV adaptation of Patayin sa Sindak si Barbara, and also served as a host in Maligno and Florinda.

Roces became recognized to new audiences as "Lola Henya" in Walang Hanggan (2012), where she shared credits with Coco Martin, Julia Montes, Helen Gamboa, Dawn Zulueta and Richard Gomez, among many others.

[16] Roces worked again with Montes in Muling Buksan ang Puso (2013) and with Martin in a 2013 Christmas episode of fantasy anthology series Wansapanataym.

Again co-starring with Coco Martin, she portrayed the key character "Lola Flora", grandmother of the series' protagonists Ador de Leon and Cardo Dalisay.

A day earlier, she was rushed to the Cardinal Santos Medical Center in San Juan, Metro Manila because of chest pain and difficulty in breathing.