[6][7] Youssef began her comedy career as a writer for The Ronnie Johns Half Hour in 2006, and made her acting debut in the short film Clicked in the role of Lina in 2011.
[14] In the same year, she hosted season two of the comedy TV series Stand and Deliver on ABC ME, which featured comedic acts from Australia and overseas.
[16][17] Later that year, she co-wrote and performed The Smallest Hour with writer and comedian Phil Spencer[a] at the Griffin in Sydney, a "comedy about broken dreams, second chances and velcro pants".
[citation needed] She has also been a guest on The Project, All Star Family Feud, Celebrity Name Game, Have You Been Paying Attention?, and Hughesy, We Have a Problem.
[22] Youssef will appear in the Australian adaptation of The Office, which is scheduled to premiere on Amazon Prime Video on 18 October 2024.
[24][8][9] In 2020, Youssef was selected as one of ten Australian comedians to compete for $100,000 on the experimental reality television series Last One Laughing Australia hosted by Rebel Wilson and screening on Amazon Prime in June.