Scouted by English club Liverpool as a teenager, Suso made his professional debut there in 2012, playing sparingly and spending a season on loan at Almería before joining AC Milan in January 2015.

[4][5] Suso made his first appearance for the first team in a pre-season friendly against Borussia Mönchengladbach on 1 August 2010, also playing in Jamie Carragher's testimonial match on 4 September.

On 20 September 2012, Suso made his senior Liverpool debut in a Europa League match against Young Boys, completing the full 90 minutes and earning a rave review from Brendan Rodgers.

He made his Premier League debut three days later against Manchester United in a 2–1 defeat at Anfield, replacing the injured Fabio Borini at half-time.

"[7] On 18 December 2012, Suso was fined £10,000 for a remark he made to Liverpool teammate and compatriot José Enrique on Twitter, which The Football Association (FA) deemed homophobic.

"[citation needed] The game finished 1–0 to United against a very strong Liverpool side that included Raheem Sterling, Andre Wisdom and Jonjo Shelvey.

[14] Late in the month, Suso scored his second goal for the Andalusians, his team's only marker in a 3–1 away loss against Celta de Vigo,[15] but was also fined for missing training due to oversleeping.

[16] Suso was then dropped to the bench in the following matches against Real Betis, Granada, Athletic Bilbao and Villarreal, only returning to the starting lineup on 26 January of the following year, assisting Jonathan Zongo in the game's only goal against Getafe.

[17] Suso was first recalled to a Liverpool matchday squad as they began their Champions League campaign on 16 September 2014 with a 2–1 win over Bulgarian club Ludogorets Razgrad, though he went unused.

[19] On 12 January 2015, Suso signed a four-year deal with Italian club AC Milan, effective upon the expiration of his contract with Liverpool, which ended in July 2015.

[21] Suso made his debut on 27 January in the quarter-finals of the Coppa Italia, replacing Michelangelo Albertazzi for the last ten minutes of a 0–1 home defeat against Lazio.

[22] Suso's Serie A debut came on 4 April, coming on alongside Giampaolo Pazzini in place of Alessio Cerci and Mattia Destro in the 77th minute of a 2–1 win away at Palermo.

[28] After being loaned out due to lack of confidence in him by Milan coach Siniša Mihajlović, Suso started getting playing time under new manager Vincenzo Montella.

[36] On 23 December 2016, Suso assisted Giacomo Bonaventura's equalising goal in the Supercoppa Italiana against Juventus; he later converted his penalty in the resulting shoot-out, leading Milan to a 4–3 victory.

During his time at AC Milan, he developed his signature move of cutting into the opponent's penalty box from the right flank to shoot with his stronger left foot.

Scoring a number of goals this way led to several comparisons of Suso with the Dutch forward Arjen Robben, who is credited with popularizing this exact technique among many younger wingers of the 2010s.