Loftus ran in the 2019 San Francisco District Attorney election, losing narrowly to criminal justice reform advocate Chesa Boudin.

[5] On October 4, 2019, Loftus was nominated to serve as Interim San Francisco district attorney.

In the 2019 San Francisco District Attorney election, Loftus and Boudin emerged as frontrunners.

Senators Dianne Feinstein and Kamala Harris, and numerous members of the California delegation to congress.

[9] Loftus was a candidate for a seat on the San Francisco Democratic County Central Committee.