The Women's 150 metre individual medley SM4 swimming events for the 2020 Summer Paralympics took place at the Tokyo Aquatics Centre on 28 August 2021.

[1] The following is a summary of the medals awarded across the 150 metre individual medley events.

[1] The SM4 category is for swimmers who have hemiplegia, paraplegia or short stature.

The swimmers with the top eight times, regardless of heat, advanced to the final.

[2]