The men's 50 metre freestyle S5 competition of the swimming events at the 2023 Parapan American Games were held on November 18, 2023, at the Aquatic Center within the Julio Martínez National Stadium in Santiago, Chile.

[1] The event includes both S4 and S5 athletes.

Prior to this competition, the existing world and Pan American Games records were as follows: The highest eight scores advance to the final.

[2] The final was held on November 18[3]