The United States is scheduled to compete in the 2023 Parapan American Games in Santiago, Chile from November 17 to 26, 2023.

The United States will be represented by 240 competitors in 16 sports at the 2023 games.

[1] Paralympic judoka Ben Goodrich and wheelchair tennis player Dana Mathewson were the country's flagbearers during the opening ceremony.

In the discipline sections below, the medalists' names are bolded.

The following is the list of number of competitors (per gender) participating at the games per sport/discipline.