Syamadas Mukhopadhyaya (22 June 1866 – 8 May 1937) was an Indian mathematician who introduced the four-vertex theorem and Mukhopadhyaya's theorem in plane geometry.

Syamadas Mukhopadhyaya was born at Haripal, Hooghly district, in Bengal Presidency, British India.

[1] Mukhopadhyaya was appointed by Asustosh Mookerjee as professor of mathematics in the Rajabazar Science College, University of Calcutta.

[2] Jacques Hadamard communicated with Mukhopadyaya about the latter's work on the geometry of a plane arc[3] and Wilhelm Blaschke's book on geometry had a reference to Mukhopadhyaya.

Mukhopadhyaya went to Europe on a Ghose Travelling Fellowship in 1933 to study methods of education.