Syracuse University multi-sport standout John Barsha was the team's franchise player.
The Pros opened their 1921 campaign, with former two-time college All American Doc Alexander playing for the team, with a scoreless tie against Tonawanda at Star Park.
A touchdown pass from player-coach Mike Purdy to Lew Andreas in the last minute of play was called back on a holding penalty, costing Syracuse a win.
To fill the first open date, manager Andy Friedman lined up a game with the Oakdales, a local semi-pro team.
In return, Syracuse played an incarnation of the Akron Indians, the one all-Native American football team, led by Suey Welch.
A new Syracuse A.C. reformed in 1902, under Frank "Buck" O'Neill, and is notable for being the first national pro football champion; using ringers such as Pop Warner and members of the Watertown Red & Black, the Syracuse A.C. upset the favorite "New York" team in round 1 of the 1902 World Series of Pro Football and went on to win the tournament.
Since the tournament was held in New York City's Madison Square Garden, the Syracuse A.C. played in the first professional indoor football game.