[2] Syzygites megalocarpus produces phototropic, repeatedly dichotomously branched sporangiophores that terminate in globose, apophysate sporangia.

Syzygites megalocarpus is likely a faculative parasite as it can be grown on a variety of media, including bread, in the laboratory.

[5] Syzygites megalocarpus is a homothallic fungus, which means each individual contains both mating loci and can therefore self-fertilize to form zygospores.

Hesseltine summarized the taxonomy of the genus in his 1957 monograph and synonymized 14 species with Syzygites megalocarpus.

[3][5] In a molecular phylogeny, Syzygites megalocarpus is placed sister to Sporodinella umbellata, albeit in a clade with Rhizopus.