A TANGO1 like protein called TALI is expressed in liver and intestine and shown to be required for the export of bulky very Low density lipoproteins (VLDL) and chylomicrons.

These findings highlight the significance of TANGO1 in building and ER exit site, controlling the quantities and quality of cargo exported, which is necessary for life.Membrane permeant peptides of TANGO1 affect hyper collagen secretion in normal and cells of patients with scleroderma, and in a zebra fish model of wound healing.

[8] MIA3 has been suggested as a tumor suppressor in malignant melanoma, colorectal cancer, and hepatoma, and induction of expression of MIA3 results in a significant decrease in motility and invasive potential.

[9][10] On the other hand, it has also been found that MIA3 promotes angiogenesis and lymphangiogenesis by upregulating platelet-derived growth factor beta (PDGF-b) polypeptide and neuropolin 2 in oral squamous cell carcinoma.

[15][16][17][18] It has been established that melanoma inhibitory gene family members serve several tumor-related functions that are subjected to a variety of human malignancies.

[11][20][21][22][23] Nevertheless, further research is needed to determine the association between melanoma inhibitory family member expression and its diagnostic, prognostic and therapeutic relevance in clinical oncology.