TIGRFAMs is a database of protein families designed to support manual and automated genome annotation.
Most models describe protein families found in Bacteria and Archaea.
[4] TIGRFAMs was produced originally at The Institute for Genomic Research (TIGR) and its successor, J. Craig Venter Institute (JCVI), but it moved in April 2018 to the National Center for Biotechnology Information (NCBI).
TIGRFAMs now continues at NCBI as part of a larger collection of HMMs, called NCBIFAMs, used in its RefSeq and PGAP genome annotation pipelines.
[5] Active curation and revision of TIGRFAMs models continues at NCBI, but the creation of TIGRFAMs models per se has ended, as newly constructed HMMs from the RefSeq group receive different designations when added to NCBIFAMs.