TMEM104 is predicted to have a promoter region 150 base pairs upstream of the start of transcription.

[7] The promoter region of Homo sapien TMEM104 compared to other organisms is very unconserved.

The protein has been located primarily in the plasma membrane and less so found in nucleus.

[8] Thermofisher claims that it exhibits significant nuclear and cytoplasmic positivity in glandular cells.

Although by no means exhaustive, this list demonstrates the enormous variety of organisms that include TMEM104 orthologs.