5515152076n/aENSMUSG00000028420Q9NVV0Q9DAV9NM_018112NM_028053NP_060582NP_082329Trimeric intracellular cation-selective channel B (TRIC-B) is a monovalent cation channel in the ER membrane encoded by the transmembrane protein 38B (TMEM38B) gene.

[4] The channel exhibits marked voltage-dependence, becoming more open when the cytosol is more positively charged than the ER lumen.

There at least four major sub-conductance states (with 80%, 60%, 46% and 30% of the conductance of the fully-opened channel).

Null mutations in TMEM38B reduce the levels of functional TRIC-B in heterozygotes and abolish expression of functional TRIC-B in homozygotes.

Such mutations are an uncommon but relatively severe cause of autosomal recessive osteogenesis imperfecta or "brittle bone disease".