The trimeric intracellular cation-selective channels or TRIC proteins are a group of homo-trimeric cation channel proteins of ~300 residues in the ER membrane.
[1] They exhibit marked voltage-dependence, becoming more open when the cytosol is more positively charged than the ER lumen.
TRIC-A is predominantly expressed in excitable tissues including brain and skeletal muscle.
[1] TRIC-A activity is thought to support RyR1-mediated efflux of Ca2+ ions from the sarcoplasmic reticulum into the cytosol.
[1] Several single-nucleotide polymorphisms (SNPs) in close proximity to the TRIC-A locus and, in future, may serve as an important biomarker in the diagnosis of essential hypertension [1] Null mutations in TMEM38B encoding TRIC-B are an uncommon but relatively severe cause of autosomal recessive osteogenesis imperfecta or "brittle bone disease".