[7] Using knockout mouse models of TNFAIP3 and its transcriptional repressor (i.e. KCHIP3), TNFAIP3 has been shown to be critical for limiting inflammation by terminating endotoxin- and TNF-induced NF-kappa B responses.

[9] TNFAIP3 has been shown to interact with TNIP1,[11] TRAF1,[12][13] TRAF2,[12] IKBKG,[14] TAX1BP1,[15] YWHAB,[16] YWHAZ,[16][17] TRAF6[13][18] and YWHAH.

[16][17] The TNFAIP3 locus is implicated as a positively associated factor in rheumatoid arthritis (RA).

[19] A third SNP, rs10499194 (T) is found less often in rheumatoid arthritis but this negative association may not be statistically meaningful.

An association with infantile onset intractable inflammatory bowel disease has also been reported.