[7][8] Members of this family are small calcium binding proteins containing EF-hand-like domains.

They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.

The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins.

In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling.

[4][11] This article incorporates text from the United States National Library of Medicine, which is in the public domain.